News & Events
Syeda presented her research as a poster at the ORS2022.
The enthesis is a transitionally graded tissue positioned between bone and tendon. The primordial enthesis develops from bi-fated progenitor cells expressing chondrogenic and tenogenic factors (i.e., Scx, Sox9, and Gli1). Created with BioRender.com.
Review published in Seminars in Cell and Developmental Biology
Our recent review paper, "Growth and mechanobiology of the tendon-bone enthesis," is now published as part of the Special Issue on Musculoskeletal Physiology, edited by Dr. Ryan Riddle. This manuscript highlights much of our current understanding of enthesis research, and highlights some new directions towards which the field is headed.
Abstract: Tendons are cable-like connective tissues that transfer both active and passive forces generated by skeletal muscle to bone. In the mature skeleton, the tendon-bone enthesis is an interfacial zone of transitional tissue located between two mechanically dissimilar tissues: compliant, fibrous tendon to rigid, dense mineralized bone. In this review, we focus on emerging areas in enthesis development related to its structure, function, and mechanobiology, as well as highlight established and emerging signaling pathways and physiological processes that influence the formation and adaptation of this important transitional tissue.
Schematic of biomaterial design for musculoskeletal regeneration, from HarleyLab.org
NIH NIAMS R01 subcontract with Dr. Brendan Harley at University of Illinois awarded!
We recently received R01 funding from the NIAMS (PI: Brendan Harley at the University of Illinois-Urbana Champaign) to translate spatially-graded biomaterials for improving enthesis regeneration in vivo! This five-year programmatic grant is an extension of an R56 that Dr. Harley received in 2020. We are excited to continue this collaborative work with folks here at Michigan Medicine (including Dr. James Carpenter) and at UIUC (including Dr. Simon Rogers). Also, this is our first multi-uni B1G funding!
The organization of the growth plate of long bones (left) resembles that of the tendon-bone interface (right).
NIH NIAMS R01 funded!
Dr. Killian is the PI on a recently awarded R01 titled: FGF signaling during growth and mechanical adaptation of tendon-bone interfaces. This project includes collaborations with Dr. David Ornitz (WUSTL) and Drs. Ken Kozloff, Sue Brooks, and Kurt Hankenson (University of Michigan).
Congratulations, Dr. Leek!
Connor Leek successfully defended his PhD work on The Role of Fibroblast Growth Factor Signaling During Superstructure Development and in Muscle-Bone Crosstalk. Read more here
Elahe awarded the Beckman Postdoctoral Fellowship!
PhD student, Elahe Ganji, was awarded the Beckman Postdoctoral Fellowship, which will support 3 years of postdoctoral training at the University of Illinois with Drs. Mariana Kersh and Kate Clancy.
Review in TMIR published!
PhD student, Connor Leek, and undergraduate students, Jaclyn Soulas and Anna Lia Sullivan, each contributed equally to a recent review entitled: Using Tools in Mechanobiology to Repair Tendons, which was published in a special issue (Cell Behavior Manipulation) in the new open-access journal, Current Tissue Microenvironment Reports.
Elahe Ganji awarded the University Doctoral Fellowship
Congratulations to Elahe Ganji, a fourth year PhD student in Mechanical Engineering (University of Delaware) on being selected for the University Doctoral Fellowship Award from the University of Delaware! This award will support Elahe for her doctoral research over the next academic year and is a competitive award. Elahe was one of two students nominated from her home department.
Professor Killian receives the prestigious NSF CAREER Award
In this CAREER project, Professor Killian will use an in vivo optogenetic platform to measure structural, mechanical, and molecular changes induced by remodeling and damage of the tendon attachment that are driven by frequency-, magnitude-, and duration-dependent changes in muscle loading, both during postnatal growth and in the mature and aging attachment.
Killian Lab at #ORS2020
The Killian Lab had a record attendance at this year's Orthopaedic Research Society Annual meeting in Phoenix, where three undergraduate and three graduate students presented their orthopaedic research.