Killian and Abraham Labs

Welcome to the Killian and Abraham Laboratories!

The Killian and Abraham Labs are a collaborative research group focused on connective tissue development and disease. Our home is in the Department of Orthopaedic Surgery and the Orthopaedic Research Laboratories at the University of Michigan Medical School. We are located at the North Campus Research Complex in Ann Arbor, Michigan.

We study musculoskeletal growth and remodeling that can be leveraged to improve tendon, muscle, bone, and joint growth and healing. We focus on the cell and tissue-scale mechanisms underlying orthopedic disorders (such as joint instability, contracture, and overuse in pediatric and young adult patients) and in chronic tendon disorders (Achilles and rotator cuff tendinopathy, as well as ACL and Achilles tendon rupture). 

We use innovative and translational tools, such as optogenetics, microphysiological systems, nano-computed tomography, confocal microscopy, molecular and cell biology, transgenic mouse models, and mechanical testing.

We train learners from a wide range of STEM backgrounds in a collaborative environment to foster individual and scientific growth.